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KMID : 0390620100180010006
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Journal of Cardiovascular Ultrasound
2010 Volume.18 No. 1 p.6 ~ p.11
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Usefulness of Mitral Annulus Velocity for the Early Detection of Left Ventricular Dysfunction in a Rat Model of Diabetic Cardiomyopathy
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Kim Dae-Hee
Kim Yong-Jin
Kim Hyung-Kwan
Chang Sung-A
Kim Min-Seok
Sohn Dae-Won
Oh Byung-Hee
Park Young-Bae
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Abstract
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Background: Diabetic cardiomyopathy (DMCMP) is characterized by myocardial dysfunction regardless of coronary arterydisease in diabetic patients. The features of LV dysfunction in rat model of type 1 DM induced by streptozocin, are variable and controversial. Thus, we tested the usefulness of tissue Doppler imaging in the early detection of ventricular dysfunction in a rat model of DMCMP.
Methods: Diabetes was induced by intra-peritoneal injection of streptozocin (70 mg/kg) in 8 weeks of Sprague-Dawley rat. Diagnosis of diabetes was defined as venous glucose level over 350 mg/dL 48 hrs after streptozocin injection. Echocardiography was done at baseline and 10 weeks after diabetes induction both in diabetes group (n=15) and normal control (n=10). After echocardiography at 10 weeks, invasive hemodynamic measurement using miniaturized conductance
catheter was done in both groups.
Results: Ten weeks after diabetes induction, heart and lung mass indexes of diabetes were larger than those of normal control (3.2±0.3 vs. 2.4±0.2 mg/g, p＜0.001, 5.5±1.1 vs. 3.6±0.6 mg/g, p＜0.001, respectively). ln echocardiographic data, s’ (2.4±0.4 vs. 3.1±0.5 cm/s, p＜0.001), e’ velocity of mitral annulus (2.9±0.6 vs. 3.8±1.1 cm/s, p＜0.001), and E/e’ ratio (27.1±5.6 vs. 19.7±2.6, p＜0.001) were impaired in diabetes group. In hemodynamic measurement, there were no differences in ejection fraction, peak dP/dt between the diabetic group and normal control. However, load independent indexes of contractility, the slope of the end-systolic pressure volume relation (0.18±0.07 vs. 0.62±0.18 mmHg/μL, p＜0.001) and preload recruitable stroke work (51.8±22.0 vs. 90.9±22.5 mmHg, p＜0.001) were impaired in diabetic group compared to normal control.
Conclusion: In a rat model of diabetic cardiomyopathy, tissue Doppler imaging of mitral annulus can be a good modality for early detection of myocardial dysfunction.
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KEYWORD
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Diabetic cardiomyopathy, Tissue Doppler imaging, Pressure-volume loop
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